look back at 123 men receiving definitive ultra-hypofractionated radiation 36.25 Gy / 5 with or without androgen deprivation therapy (ADT) for predominantly intermediate risk prostate cancer found three pre-treatment multiparametric prostate MRI parameters to be highly predictive of post-treatment PSA nadir and time to PSA nadir: PI-RADS score, prostate lesion size, and number of prostate lesions. This adds to prior data suggesting prostate lesion size—something we could visualize only recently—may one day impact decisions on aggressiveness of treatment such as when to incorporate a targeted dose-escalated boost. | Rayn, Adv Radiat Oncol 2023
