A single-arm phase 2 trial at MSKCC suggests hypofractionated ablative radiation (4.5 Gy x 15 = 67.5 Gy if >1 cm from bowel or 3 Gy x 25 = 75 Gy in not) for locally advanced pancreatic cancer remaining unresectable after induction chemotherapy is a reasonable consolidation strategy that preserves the option of surgery while providing durable local control and encouraging survival outcomes for those who ultimately never undergo resection. | Reyngold, JAMA Surg 2026
