Top Line: Optimizing tumor control without thwarting wound healing is a fine balance for post-op radiosurgery for resected brain mets.
The Study: This look back at a prospective cohort of 61 patients receiving “rapid” post-op radiosurgery within 30 days (median 14 days) from resection of a brain met demonstrated no difference in local failure and adverse event rates when compared with an historical control of 377 patients receiving standard post-op radiosurgery. When looking at all patients (n=438), receipt of radiation within 14 days carried the highest risk of adverse events (18%) and within 22 to 30 days the lowest (4%). On the other hand, local failure was the highest for those receiving radiation >30 days from surgery (11%) and comparable for those receiving radiation at any point ≤30 days: 5% ≤14 days, 3% 15-21 days, and 7% 22-30 days.
TBL: “The findings of this study suggest that [22-30 days from surgery] allows for a balanced approach that minimizes the risks associated with local failure and posttreatment adverse radiation effects.” | Bander, JAMA Netw Open 2023
The Study: This look back at a prospective cohort of 61 patients receiving “rapid” post-op radiosurgery within 30 days (median 14 days) from resection of a brain met demonstrated no difference in local failure and adverse event rates when compared with an historical control of 377 patients receiving standard post-op radiosurgery. When looking at all patients (n=438), receipt of radiation within 14 days carried the highest risk of adverse events (18%) and within 22 to 30 days the lowest (4%). On the other hand, local failure was the highest for those receiving radiation >30 days from surgery (11%) and comparable for those receiving radiation at any point ≤30 days: 5% ≤14 days, 3% 15-21 days, and 7% 22-30 days.
TBL: “The findings of this study suggest that [22-30 days from surgery] allows for a balanced approach that minimizes the risks associated with local failure and posttreatment adverse radiation effects.” | Bander, JAMA Netw Open 2023