What are the optimal total doses for a given number of fractions to achieve maximal tumor control of NSCLC? This study validated HyTEC tumor control probabilities for NSCLC using data from nearly 10,000 patients treated with everything from conventional fractionation to SBRT. It includes a table of optimal total doses for a given number of fractions. An initial takeaway is the finding that an alpha-beta of ~20Gy appears to best fit the TCP data. Beginning at a BED20 of 50-60Gy, tumor control increases rapidly until plateauing at a BED20 of ~100Gy. While it basically confirmed what we already know about high and low-BED control probabilities, it provided interesting insights into the less explored areas of hypofractionation in the medium-BED range. As you might expect, the model predicted that higher hypofractionated doses such as 60Gy in 10 fractions up to 70Gy in 20 fractions are necessary to optimize control. | Liu, Int J Radiat Oncol Biol Phys 2023
