A large retrospective cohort of patients receiving brain radiosurgery suggests lesions that enlarge later (median 8 versus 6 months), occur in patients receiving immunotherapy, were encompassed by smaller treatment volumes, and are asymptomatic are more likely to represent radionecrosis versus local recurrence with the former–as expected–portending much longer survival times (median 40 versus 15 months). | Leng, Adv Radiat Oncol 2026
