This pan-cancer analysis integrated radiosensitivity data from over 100 cancer cell lines and TCGA clinical data from over 500 irradiated male patients. Tumor loss of the Y chromosome was associated with increased post-radiotherapy survival of cancer cells. Transcriptomically, LOY tracked with altered DNA damage response, senescence, longevity, and proliferation pathways. | Bourbonne, Int J Radiat Oncol Biol Phys 2026
