The same group again shows that immune checkpoint inhibition is fine during radiosurgery. What’s more interesting was the clear correlation with incidence of radionecrosis and volume of brain receiving ≥12 Gy (V12 Gy). Here the V12 Gy included the target volume and did not need to be contiguous. Risks of radionecrosis at one and two years when V12 Gy was <12 cc were 4% and 8%, when 12-20 cc were 10% and 14%, and when >20 cc were 13% and 15%.
- Lehrer, Int J Radiat Oncol 2023