Here is a Swiss prospective evaluation of 424 consecutive women receiving whole breast irradiation of 40 Gy in 15 fractions for stage 0-III breast cancer. The kicker is they all got a simultaneous daily boost to the lumpectomy cavity to a total of 48 Gy. Of note, comprehensive nodal regions were included when indicated using the same fractionation. What’s more, almost all women were treated with 3D techniques with a daily cone down using static fields. The only late grade 3 toxicity was one event of breast edema. Excellent to good cosmesis was achieved in 97% of women out to 4 years. At 3 years, disease-free survival was 96% and locoregional recurrence rate only 0.6%. | Unterkirhere, Adv Radiat Oncol 2023
