This review summarizes everything you never knew you needed to know about Barret’s esophagus including aggressive PPI (i.e. high-dose esomeprazole 40 mg twice daily) until symptom resolution and surveillance endoscopy “at intervals determined by the length of the affected segment (3 years for a segment of ≥3 cm and 5 years for a short segment of 1 to <3 cm) or treatment [i.e., radiofrequency ablation or historical photodynamic therapy] if dysplasia is identified and confirmed.” | Fitzgerald, N Engl J Med 2026
