While circulating plasma tumor HPV-DNA has garnered a lot of attention as a sensitive way to monitor for head and neck recurrence following treatment, combining it with tumor DNA fragment analysis is thought to be even more accurate. This retrospective analysis demonstrates this combination has 100% specificity when used either at initial diagnosis or in post-treatment surveillance while sensitivity was 92% and 88%, respectively. | Ferrandino, JAMA Otolaryngol Head Neck Surg 2023
