This thought-provoking retrospective cohort suggests serum (yes, circulating soluble) PD-L1 is uniquely elevated in patients with aggressive, as opposed to indolent, papillary thyroid carcinoma—particularly disease with gross extrathyroidal extension and aggressive histology—positioning serum PD-L1 as a potential adjunctive marker for identifying biologically aggressive disease prior to surgery. | Vasudevan, JAMA Otolaryngol Head Neck Surg 2026
