Tha phase 2 OPRA trial delves into compliance and toxicity rates with both sequencing strategies. Unsurprisingly, more people initiated chemoradiation when it came first (98 v 93%) while more people initiated chemo when it came first (99 v 94%). There was no statistical difference in graded 3+ toxicity with chemoradiation first (34%) versus chemo first (41%). | Verheji, Int J Radiat Oncol Biol Phys 2023
