This topic discussion makes an intriguing (and persuasive) argument that, given peri-rectal nodal metastases are encountered more often in the PSMA-PET era than previously recognized in intermediate and high-risk prostate cancers–and, in fact, comprise as much as 13% of all metastatic nodal sites–an involved peri-rectal node should prompt consideration of elective coverage of the entire mesorectum. | Shen, Pract Radiat Oncol 2026
