A secondary analysis of three major NRG/RTOG trials provides further evidence that interruptions in head and neck radiotherapy—especially week-long breaks—were associated with significantly higher locoregional failure and worse overall survival, with persistent relative risk across HPV-status, meaning the stakes are highest for advanced-stage HPV-negative disease which saw a >10% absolute reduction in disease control after a treatment interruption. | Gharzai, JAMA Otolaryngol Head Neck Surg 2025
