Most folks were left confused after a recent Alliance trial reported significantly worse (and just overall bad) local control with post-op radiosurgery versus whole brain radiation; well, a central review of post-radiation imaging is here to say, oops! A solid one in three patients initially deemed to have local failure actually didn’t, leaving local control similar between arms (79% after radiosurgery versus 87% after whole brain at 12 months).
TBL: IRMA confirms that fair/poor cosmesis is slightly higher when APBI is delivered using 38.5 Gy in 10 BID fractions.
Citation(s)
- Breen, ASTRO 2022