Is 8 Gy x 1 an effective palliative regimen for mycosis fungoides (MF)? In this retrospective review, 46 patients with MF had 242 lesions treated with 8Gy x 1. Most lesions were treated with 6MeV or 9MeV typically with 0.5cm bolus. The majority (85.1%) had an immediate complete response. The rest (14.9%) received repeat 8Gy x 1 at a median of 8 weeks after initial treatment and 50% of those lesions had a complete response. So, after a median follow up of 24.6 months, the overall complete response rate to 8Gy x 1 with an additional 8Gy x 1 8 weeks later for nonresponders was 92.6%. Over that follow up time period, no patients experienced local recurrence. Depending on the overall treatment goals, 8Gy x 1 is an effective and durable palliative option with a minority of patients requiring retreatment. | Wang, Pract Radiat Oncol 2023
