Here’s a retrospective look at 25 women receiving repeat lumpectomy followed by VMAT-based partial breast re-irradiation to 26 Gy in 5 fractions for an ipsilateral breast tumor recurrence after prior breast-conserving surgery and radiation. These recurrences generally meet all other criteria for PBI appropriateness. At a median follow-up surpassing one year, only 3 patients experienced a downgrade in scored cosmesis and local control was superb. This supports ultra-hypofractionated partial breast re-irradiation as an option worth discussing with carefully selected patients with favorable ipsilateral breast recurrences with long disease-free intervals motivated to avoid mastectomy. | Oyeniyi, Adv Radiat Oncol 2026
