Data is mixed on whether reducing dose to bone marrow reduces hematologic toxicity. In this study of 132 patients who received thoracic radiation for NSCLC, dosimetry for the thoracic vertebral bodies was analyzed to determine if there was an association with hematologic toxicity. Overall, 19.7% experienced grade 3+ hematologic toxicity. Mean dose to the vertebral bodies and V5-V20 were associated with heme toxicity. Exceeding the following thresholds was associated with double the risk of grade 3+ heme toxicity: Dmean >30.2Gy, V5 >69.1%, V10 >64.6%, and V20 >53.5%. | Ma, Int J Radiat Oncol Biol Phys 2023
