A Swedish prospective cohort study reports a negative colonoscopy following a positive fecal occult blood test is associated with a low risk of subsequent colon cancer, while patients with a positive FOBT who fail to present for colonoscopy evaluation are at 4x higher risk than general public, suggesting screening efforts for patients with a positive FOBT should be concentrated on ensuring initial follow-up colonoscopy rather than ongoing intensified surveillance. | Heyman, JAMA Netw Open 2026
