A large cross-sectional study demonstrates men with high-risk (read: PSA ≥2.0 ng/mL above post-definitive radiotherapy nadir or ≥1.0 ng/mL after salvage radiation, PSA doubling time ≤9 months, and testosterone ≥150 ng/dL) biochemical recurrence have a nearly 50% chance of discovering distant mets (half being 5+ mets) with PSMA-PET staging. | Holzgreve, JAMA Netw Open 2025
