In this trial, 17.4% of breast cancer patients who underwent immediate lymphatic reconstruction followed by regional nodal irradiation developed chronic lymphedema. Those who developed lymphedema had significantly higher mean dose (41 Gy v 14 Gy in 15 fractions), V35 (89% v 20%), and V40 (84% v 17%) at the lymphatic anastomosis site. | Spiegel, Int J Radiat Oncol Biol Phys 2026
