Top Line: A recent case report caused quite the kerfuffle over the theoretical advantages and disadvantages of today’s popular carotid-sparing intensity modulated radiation (IMRT) for early-stage laryngeal cancer.
The Study: This meta-analysis is here to bring robust data to the conversation. It included a total of 14 retrospective and one prospective study of definitive radiation for early-stage glottic cancer including 873 patients receiving IMRT and 738 receiving conventional radiation. When looking at studies reporting outcomes for both modalities, there was no difference in local or regional control. The estimated local failure rate at 5 years after IMRT was 9%, more common with T2 or high-grade disease. The crude rate of regional failure after IMRT was 1.5% and after conventional radiation was 1.9%.
TBL: “This study provides the strongest level of evidence to date to support the efficacy of IMRT in early stage glottic larynx cancer.” | Razavian, Int J Radiat Oncol Biol Phys 2023
The Study: This meta-analysis is here to bring robust data to the conversation. It included a total of 14 retrospective and one prospective study of definitive radiation for early-stage glottic cancer including 873 patients receiving IMRT and 738 receiving conventional radiation. When looking at studies reporting outcomes for both modalities, there was no difference in local or regional control. The estimated local failure rate at 5 years after IMRT was 9%, more common with T2 or high-grade disease. The crude rate of regional failure after IMRT was 1.5% and after conventional radiation was 1.9%.
TBL: “This study provides the strongest level of evidence to date to support the efficacy of IMRT in early stage glottic larynx cancer.” | Razavian, Int J Radiat Oncol Biol Phys 2023