Browsing: IDH

Top Line: Prior to IDH mutation and 1p/19q codeletion testing for low grade gliomas, prognostication relied on clinical and pathologic…

Top Line: What are the long term outcomes with RT alone or TMZ alone for high risk, low grade glioma?The…

Top Line: What is the benefit of concurrent and adjuvant temozolomide for high grade astrocytoma?The Study: Anaplastic (Grade 3) astrocytomas…

In the INDIGO trial, vorasidenib, an oral IDH 1/2 inhibitor, significantly prolonged median PFS and time to next intervention compared…

Top Line: Ah, INDIGO, the exciting but confusing trial designed to demonstrate the efficacy of vorasidenib, an oral IDH-inhibitor, for…

Top Line: How should the IDH-status of lower-grade glioma (not classified as GBM) influence decisions about systemic therapy, if at…

Isocitrate dehydrogenase (IDH)-status of gliomas is a well-recognized prognostic indicator of outcomes. In fact, in recent years it has come…