Does CSI improve survival in patients with leptomeningeal disease?
In a phase 2 trial of metastasis directed therapy alone (no systemic therapy) for oligometastatic clear cell RCC, what was the median systemic therapy free survival?
Does a rectal spacer improve rectal dosimetry during brachytherapy for cervical cancer?
In the SUNSET trial of 60 Gy in 8 fractions for ultracentral NSCLC, what was the biggest dosimetric predictor of toxicity risk?
Answers
Yes, in the right setting. In this trial of patients with mostly breast and NSCLC, proton CSI significantly improved median OS (11 v 5 months) compared to focal photon radiation to involved sites only.
34 months. Median PFS was 17.7 months, but 59% of patients were eligible for a second round of MDT.
Yes. Rectal D0.01cc, D2cc, and D5cc were all lower with the spacer, however rates of acute and late rectal toxicity were similar.
Nothing. Within the OAR constraints used on the trial, which were prioritized over target coverage, there was no good dosimetric predictor of toxicity. The rate of grade 3-5 toxicity was 6.7%. | QuadShot News
In a phase 2 trial of metastasis directed therapy alone (no systemic therapy) for oligometastatic clear cell RCC, what was the median systemic therapy free survival?
Does a rectal spacer improve rectal dosimetry during brachytherapy for cervical cancer?
In the SUNSET trial of 60 Gy in 8 fractions for ultracentral NSCLC, what was the biggest dosimetric predictor of toxicity risk?
Answers
Yes, in the right setting. In this trial of patients with mostly breast and NSCLC, proton CSI significantly improved median OS (11 v 5 months) compared to focal photon radiation to involved sites only.
34 months. Median PFS was 17.7 months, but 59% of patients were eligible for a second round of MDT.
Yes. Rectal D0.01cc, D2cc, and D5cc were all lower with the spacer, however rates of acute and late rectal toxicity were similar.
Nothing. Within the OAR constraints used on the trial, which were prioritized over target coverage, there was no good dosimetric predictor of toxicity. The rate of grade 3-5 toxicity was 6.7%. | QuadShot News