In a pooled analysis comparing ultrahypofractionated prostate RT and HDR brachytherapy, did either modality have worse biochemical failure?
A large analysis of SRS for brainstem metastases found what rate of grade 3+ adverse events?
In the CONVERT trial, was there a difference in locoregional recurrence free survival with neoadjuvant CAPOX alone versus neoadjuvant chemoradiation for low risk rectal cancer?
What was the risk of local recurrence and distant recurrence in a recent trial comparing SRS and HA-WBRT for multiple brain metastases?
Answers
Yes, biochemical failure was significantly higher with HDR-brachy at 5 years (8% versus 3%) and 10 years (38% versus 10%).
3.1%. The most frequent regimens used in the study were 16 Gy in 1 and 24 Gy in 3 fractions. However, TCP modelling estimated a dose of 20.5 Gy in 1 fraction or 28.2 Gy in 3 fractions would be necessary for 90% control at 2 years.
No. At 3 years it was 97.4% CRT v 96.3% CT, though this technically didn’t reach the threshold for noninferiority.
There were more new distant brain mets at 1 year after SRS (45%) than HA-WBRT (24%), but much lower local recurrence (0.8% versus 12.3%). SRS also achieved better functional independence and performance status over time. | QuadShot News
A large analysis of SRS for brainstem metastases found what rate of grade 3+ adverse events?
In the CONVERT trial, was there a difference in locoregional recurrence free survival with neoadjuvant CAPOX alone versus neoadjuvant chemoradiation for low risk rectal cancer?
What was the risk of local recurrence and distant recurrence in a recent trial comparing SRS and HA-WBRT for multiple brain metastases?
Answers
Yes, biochemical failure was significantly higher with HDR-brachy at 5 years (8% versus 3%) and 10 years (38% versus 10%).
3.1%. The most frequent regimens used in the study were 16 Gy in 1 and 24 Gy in 3 fractions. However, TCP modelling estimated a dose of 20.5 Gy in 1 fraction or 28.2 Gy in 3 fractions would be necessary for 90% control at 2 years.
No. At 3 years it was 97.4% CRT v 96.3% CT, though this technically didn’t reach the threshold for noninferiority.
There were more new distant brain mets at 1 year after SRS (45%) than HA-WBRT (24%), but much lower local recurrence (0.8% versus 12.3%). SRS also achieved better functional independence and performance status over time. | QuadShot News