What was the rate of freedom from local recurrence after 50 Gy in 10 fractions for HCC that wasn’t eligible for 50 Gy in 5 fractions in a recent VA series?
Does regorafenib improve survival in newly diagnosed, unmethylated GBM or recurrent GBM?
In a recent cohort of patients treated with de-escalated RT for p16+ oropharyngeal cancer, what proportion of recurrences happened 2 years or more after treatment?
In recent retrospective study comparing different dose-fractionation regimens for SCLC, did BID dose escalation have better survival?
Answers
82% at 2 years vs 91% for lesions that received 50 Gy in 5 fractions, though the latter had more favorable tumor characteristics.
No. In the GBM AGILE trial, regorafenib did not significantly improve OS when given as adjuvant therapy after chemoradiation for new GBM or in the recurrent setting when compared to lomustine.
46%. However, at 5 years the locoregional recurrence rate was just 3.4% among a favorable cohort of patients treated with 60 Gy in 30 fractions +/- chemotherapy.
Yes. 54 Gy in 30 BID fractions outperformed 45 Gy in 30 BID fractions and 60-70 Gy in daily fractions. | QuadShot News
Does regorafenib improve survival in newly diagnosed, unmethylated GBM or recurrent GBM?
In a recent cohort of patients treated with de-escalated RT for p16+ oropharyngeal cancer, what proportion of recurrences happened 2 years or more after treatment?
In recent retrospective study comparing different dose-fractionation regimens for SCLC, did BID dose escalation have better survival?
Answers
82% at 2 years vs 91% for lesions that received 50 Gy in 5 fractions, though the latter had more favorable tumor characteristics.
No. In the GBM AGILE trial, regorafenib did not significantly improve OS when given as adjuvant therapy after chemoradiation for new GBM or in the recurrent setting when compared to lomustine.
46%. However, at 5 years the locoregional recurrence rate was just 3.4% among a favorable cohort of patients treated with 60 Gy in 30 fractions +/- chemotherapy.
Yes. 54 Gy in 30 BID fractions outperformed 45 Gy in 30 BID fractions and 60-70 Gy in daily fractions. | QuadShot News