Does pluvicto improve radiographic PFS in patients with metastatic, castration sensitive prostate cancer receiving ADT and an androgen receptor blocker?
Is age prognostic of outcome in patients with IDH-mutated low grade glioma?
Does dual immune checkpoint inhibition (TIGIT and PD-1) improve outcomes compared to standard adjuvant durvalumab after chemoradiation for stage III NSCLC?
In fit patients with GBM, is ultrahypofractionated radiation comparable to the standard 60 Gy in 30 fractions?
Answers
Yes. In PSMAddition, adding pluvicto had a 28% relative reduction in rPFS.
No. Though prognostic in the premolecular era, this was likely because patients over 40 were more likely to have IDH wild type gliomas and adverse molecular features.
No. In SKYSCRAPER-03, adjuvant tiragolumab and atezolizumab did not significantly improve PFS when compared to durvalumab.
No. In the GOLD trial, survival was significantly worse after 36/24 Gy in 6 fractions compared with 60 Gy in 30 fractions (13 v 21 months). There was also significantly more radionecrosis with ultrahypofractionation (48% v 16%). | QuadShot News
Is age prognostic of outcome in patients with IDH-mutated low grade glioma?
Does dual immune checkpoint inhibition (TIGIT and PD-1) improve outcomes compared to standard adjuvant durvalumab after chemoradiation for stage III NSCLC?
In fit patients with GBM, is ultrahypofractionated radiation comparable to the standard 60 Gy in 30 fractions?
Answers
Yes. In PSMAddition, adding pluvicto had a 28% relative reduction in rPFS.
No. Though prognostic in the premolecular era, this was likely because patients over 40 were more likely to have IDH wild type gliomas and adverse molecular features.
No. In SKYSCRAPER-03, adjuvant tiragolumab and atezolizumab did not significantly improve PFS when compared to durvalumab.
No. In the GOLD trial, survival was significantly worse after 36/24 Gy in 6 fractions compared with 60 Gy in 30 fractions (13 v 21 months). There was also significantly more radionecrosis with ultrahypofractionation (48% v 16%). | QuadShot News