When the PORTOS radiation response signature was run on breast cancer tumors that did or did not receive adjuvant breast radiation, what percentile of scores benefited from radiation?
In a trial that tested multiple rounds of the quad shot regimen for symptomatic central lung tumors in the setting of metastatic disease, what amount of time was given between cycles?
In GU005, did prostate SBRT have less decline in urinary or bowel domains when compared to moderate hypofractionation?
Does adjuvant therapy improve outcomes for RET fusion positive NSCLC after definitive surgery or radiation?
Answers
The upper 75% of all scores benefited from RT while the lower 25% did not.
3-4 weeks with 14.8 Gy given in 4 fractions BID over 2 days. There were no grade 3 events among those who received 3 cycles.
Less decline in bowel domains (34.9% v 43.8%), but similar frequency of decline in urinary domains (35.4% v 33.7%). DFS at 3 years was 88.6% for SBRT and 92.1% for IMRT.
Yes, selpercatinib improved EFS at 2 years from 70% to 92%, and a large benefit was seen in those with stage II-IIIA disease (92% v 61%). | QuadShot News
In a trial that tested multiple rounds of the quad shot regimen for symptomatic central lung tumors in the setting of metastatic disease, what amount of time was given between cycles?
In GU005, did prostate SBRT have less decline in urinary or bowel domains when compared to moderate hypofractionation?
Does adjuvant therapy improve outcomes for RET fusion positive NSCLC after definitive surgery or radiation?
Answers
The upper 75% of all scores benefited from RT while the lower 25% did not.
3-4 weeks with 14.8 Gy given in 4 fractions BID over 2 days. There were no grade 3 events among those who received 3 cycles.
Less decline in bowel domains (34.9% v 43.8%), but similar frequency of decline in urinary domains (35.4% v 33.7%). DFS at 3 years was 88.6% for SBRT and 92.1% for IMRT.
Yes, selpercatinib improved EFS at 2 years from 70% to 92%, and a large benefit was seen in those with stage II-IIIA disease (92% v 61%). | QuadShot News