Have you ever wondered if brain-only progression is less important than extracranial progression when assessing overall disease trajectory and remaining life expectancy? After all, in 2023 radiosurgery to isolated intracranial disease often means no need for a change in systemic therapy with very little change in a patient’s overall quality of life. This multi-institutinal retrospective study actually found that both intracranial PFS and extracranial PFS were highly correlated with OS. Half had intracranial progression that preceded 49% of deaths while 58% had extracranial progression preceding 63% of deaths. | Carpenter, JAMA Netw Open 2023
