We’ve long known exercise is good medicine during and after cancer treatment, but CHALLENGE provided cold hard facts to bolster conventional wisdom. You’ll recall this multicenter phase 3 trial demonstrated a 3-year supervised aerobic exercise program with regular consultant check-ins and behavioral coaching for patients finishing adjuvant chemo for stage II-III colon cancer significantly improved overall survival, driven by fewer distant mets and fewer second primaries. This much-needed commentary highlights the next challenge: building the infrastructure—trained exercise professionals, triage pathways, reimbursement models, and credentialed programs—so clinicians can actually prescribe evidence-based exercise oncology rather than good intentions. | Schmitz, J Clin Oncol 2025
