Top Line: Is adjuvant gemcitabine and cisplatin superior to ciplatin and 5FU for locally advanced nasopharyngeal carcinoma?
The Study: Induction gemcitabine and cisplatin followed by chemoradiation is the NCCN preferred treatment option for locally advanced nasopharyngeal carcinoma, especially EBV-mediated disease, as is improves overall survival compared to chemoradiation alone. Adjuvant chemotherapy with cisplatin and 5FU is another option used in many patients. This randomized, phase 3 trial!https://doi.org/10.1016/S1470-2045(23)00232-2
TBL: Adjuvant gem/cis after chemoradiation for NPC improves PFS compared to adjuvant cis/5FU. | Liu, Lancet Oncol 2023
The Study: Induction gemcitabine and cisplatin followed by chemoradiation is the NCCN preferred treatment option for locally advanced nasopharyngeal carcinoma, especially EBV-mediated disease, as is improves overall survival compared to chemoradiation alone. Adjuvant chemotherapy with cisplatin and 5FU is another option used in many patients. This randomized, phase 3 trial!https://doi.org/10.1016/S1470-2045(23)00232-2
TBL: Adjuvant gem/cis after chemoradiation for NPC improves PFS compared to adjuvant cis/5FU. | Liu, Lancet Oncol 2023