This editorial is here to remind us level I randomized evidence from NRG-RTOG 1114 supports reintroducing low-dose whole brain radiation (23.4 Gy in 13 fractions) as an upfront consolidation strategy for primary CNS lymphoma–particularly for those ineligible for aggressive stem cell transplants–as it dramatically prolongs progression-free survival with the neurocognitive hit historically associated with higher-dose whole brain radiation. | Cederquist, Int J Radiat Oncol Biol Phys 2026
